Multi-triazole-resistant Aspergillus fumigatus and SARS-CoV-2 co-infection: A lethal combination

Aia Mohamed; Tidi Hassan; Marta Trzos-Grzybowska; Jubil Thomas; Aidan Quinn; Maire O'Sullivan; Auveen Griffin; Thomas R Rogers; Alida Fe Talento

doi:10.1016/j.mmcr.2020.06.005

Multi-triazole-resistant Aspergillus fumigatus and SARS-CoV-2 co-infection: A lethal combination

Med Mycol Case Rep. 2021 Mar:31:11-14. doi: 10.1016/j.mmcr.2020.06.005. Epub 2020 Jun 26.

Authors

Aia Mohamed¹, Tidi Hassan², Marta Trzos-Grzybowska¹, Jubil Thomas³, Aidan Quinn⁴, Maire O'Sullivan^{5

6}, Auveen Griffin⁵, Thomas R Rogers^{5

6}, Alida Fe Talento^{1

7}

Affiliations

¹ Department of Microbiology, Our Lady of Lourdes Hospital Drogheda, Co. Louth, Ireland.
² Department of Medicine, Our Lady of Lourdes Hospital Drogheda, Co. Louth, Ireland.
³ Department of Anaesthesia and Intensive Care, Our Lady of Lourdes Hospital Drogheda, Co. Louth, Ireland.
⁴ Department of Radiology, Our Lady of Lourdes Hospital Drogheda, Co. Louth, Ireland.
⁵ Department of Microbiology, St. James's Hospital, Dublin, Ireland.
⁶ Deparment of Clinical Microbiology, Trinity College Dublin, Dublin, Ireland.
⁷ Department of Microbiology, Royal College of Surgeons, Ireland, Dublin, Ireland.

Abstract

We report a case of severe COVID-19 pneumonia complicated by fatal co-infection with a multi-triazole resistant Aspergillus fumigatus and highlight the importance of recognising the significance of Aspergillus sp. isolation from respiratory samples. Early diagnosis and detection of triazole resistance are essential for appropriate antifungal therapy to improve outcome in patients with coronavirus associated invasive aspergillosis.

Keywords: COVID-19 pneumonia; Invasive pulmonary aspergillosis; Multi-triazole resistance.

Publication types

Case Reports