Identification of a hotspot on PD-L1 for pH-dependent binding by monoclonal antibodies for tumor therapy

Signal Transduct Target Ther. 2020 Aug 24;5(1):158. doi: 10.1038/s41392-020-00254-z.

Hongchuan Liu^#^{1

2}, Xiaoshan Bi^#^{3

4}, Yuehua Zhou², Rui Shi⁴, Sheng Yao², Jianxun Qi⁵, Hui Feng², Meiqing Feng⁶, Jinghua Yan^{7

8

9}, Shuguang Tan^{10

11}

¹ Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, 201203, Shanghai, China.
² Department of Antibody Discovery and Engineering, Shanghai Junshi Biosciences Co., Ltd, 201203, Shanghai, China.
³ School of Life Sciences, Anhui University, 230601, Hefei, China.
⁴ CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China.
⁵ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China.
⁶ Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, 201203, Shanghai, China. fmq@fudan.edu.cn.
⁷ School of Life Sciences, Anhui University, 230601, Hefei, China. yanjh@im.ac.cn.
⁸ CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China. yanjh@im.ac.cn.
⁹ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China. yanjh@im.ac.cn.
¹⁰ School of Life Sciences, Anhui University, 230601, Hefei, China. tansg@im.ac.cn.
¹¹ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China. tansg@im.ac.cn.

^# Contributed equally.

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