Among patients with coronavirus disease (COVID-19), IgM levels increased early after symptom onset for those with mild and severe disease, but IgG levels increased early only in those with severe disease. A similar pattern was observed in a separate serosurveillance cohort. Mild COVID-19 should be investigated separately from severe COVID-19.
Keywords: 2019 novel coronavirus disease; Atlanta; COVID-19; Georgia; SARS-CoV-2; USA; antibody profiles; coronavirus disease; immunoglobulin; infection severity; neutralization; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.