The correlation between novel peripheral blood cell ratios and 90-day mortality in patients with acute ischemic stroke

PLoS One. 2020 Aug 28;15(8):e0238312. doi: 10.1371/journal.pone.0238312. eCollection 2020.

Abstract

Background: We aimed to investigate the correlation between the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet-to-neutrophil ratio (PNR), platelet-to-white blood cell ratio (PWR) and 90-day mortality in patients with acute ischemic stroke (AIS).

Methods: We retrospectively included 633 patients with AIS from January 2017 to May 2018. The correlation between each indicator and the degree of neurologic deficit was assessed. Kaplan-Meier survival curves based on blood cell ratios were used to analyze the 90-day survival rate of patients with AIS.

Results: A total of 663 patients with AIS were enrolled, of which 24 (3.6%) experienced recurrence and 13 (2.0%) died. NLR>3.23 (odds ratio; OR = 2.236; 95% confidence interval [CI], 1.472-3.397; P<0.001), PNR<31.14 (OR = 0.471; 95% CI, 0.297-0.749; P = 0.001), and PWR<20.62 (OR = 0.498; 95% CI, 0.309-0.800; P = 0.004) were associated with an unfavorable 90-day prognosis. NLR>3.23, PWR<20.62, and PNR<31.14 were associated with an increased risk of 90-day mortality.

Conclusion: PNR, PWR, and NLR were associated with the 90-day mortality of patients with AIS. Patients with high NLRs or low PWRs and PNRs may have a greater risk of mortality than other patients. These clinical indicators may help clinicians judge unfavorable prognosis early and implement the appropriate interventions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Blood Cell Count
  • Brain Ischemia / blood*
  • Brain Ischemia / mortality*
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Recurrence
  • Retrospective Studies
  • Stroke / blood*
  • Stroke / mortality*
  • Young Adult

Substances

  • Biomarkers

Grants and funding

This work was supported by grants from National Administration of Traditional Chinese Medicine(2019XZZX-NB007), 333 high level talents training project in Jiangsu (BRA2016507), Jiangsu Province Administration of Chinese Medicine (ZX2016A2). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.