CHI3L1 in the pathophysiology and diagnosis of liver diseases

Shuwei Wang; Mengyuan Hu; Yunsong Qian; Zhenluo Jiang; Lili Shen; Liyun Fu; Yaoren Hu

doi:10.1016/j.biopha.2020.110680

CHI3L1 in the pathophysiology and diagnosis of liver diseases

Biomed Pharmacother. 2020 Nov:131:110680. doi: 10.1016/j.biopha.2020.110680. Epub 2020 Aug 28.

Authors

Shuwei Wang¹, Mengyuan Hu², Yunsong Qian¹, Zhenluo Jiang¹, Lili Shen¹, Liyun Fu³, Yaoren Hu⁴

Affiliations

¹ Department of Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China; Medical School of Ningbo University, Ningbo 315211, China.
² Medical School of Ningbo University, Ningbo 315211, China.
³ Department of Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China; Ningbo Institute of Life and Health Industry, University of Chinese Academy of Science, Ningbo 315010, China; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo 315010, China; Ningbo Clinical Research Center for Digestive System Tumors (Grant No.2019A21003), Ningbo 315010, China. Electronic address: fuliyun@ucas.ac.cn.
⁴ Department of Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China; Ningbo Institute of Life and Health Industry, University of Chinese Academy of Science, Ningbo 315010, China; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo 315010, China; Ningbo Clinical Research Center for Digestive System Tumors (Grant No.2019A21003), Ningbo 315010, China. Electronic address: hu510@126.com.

PMID: 32861071
DOI: 10.1016/j.biopha.2020.110680

Abstract

Chitinase 3-like protein 1(CHI3L1) participates in physiological and pathophysiological process, such as cell survival, cell proliferation, tissue remodeling, angiogenesis, etc. Some studies demonstrated that CHI3L1 is liver-enriched and has better application value in staging liver fibrosis than platelet ratio index(APRI) and ﬁbrosis-4 index(FIB-4) and that CHI3L1 can be used in monitoring the prognosis of hepatocellular carcinoma (HCC). In this review, we summarized the pathophysiological role and the diagnostic value of CHI3L1 in liver fibrosis in different background and HCC.

Keywords: Biomarker; CHI3L1; Hepatocellular carcinoma; Liver fibrosis; Mechanism.

Publication types

Review

MeSH terms

Biomarkers / metabolism
Carcinoma, Hepatocellular / diagnosis
Carcinoma, Hepatocellular / metabolism
Carcinoma, Hepatocellular / physiopathology
Chitinase-3-Like Protein 1 / metabolism*
Growth Substances / metabolism*
Humans
Liver Cirrhosis / diagnosis*
Liver Cirrhosis / metabolism*
Liver Cirrhosis / physiopathology
Liver Diseases / diagnosis
Liver Diseases / metabolism
Liver Diseases / physiopathology
Liver Neoplasms / diagnosis
Liver Neoplasms / metabolism
Liver Neoplasms / physiopathology

Substances

Biomarkers
CHI3L1 protein, human
Chitinase-3-Like Protein 1
Growth Substances