The Jekyll and Hyde of TREM2

Javier Rueda-Carrasco; Soyon Hong

doi:10.1016/j.tins.2020.08.002

The Jekyll and Hyde of TREM2

Trends Neurosci. 2020 Oct;43(10):739-740. doi: 10.1016/j.tins.2020.08.002. Epub 2020 Aug 27.

Authors

Javier Rueda-Carrasco¹, Soyon Hong²

Affiliations

¹ UK Dementia Research Institute at University College London, Institute of Neurology, Gower Street, London WC1E 6BT, UK.
² UK Dementia Research Institute at University College London, Institute of Neurology, Gower Street, London WC1E 6BT, UK. Electronic address: soyon.hong@ucl.ac.uk.

PMID: 32863043
DOI: 10.1016/j.tins.2020.08.002

Abstract

In a recent paper, Gratuze et al. demonstrated a putative neuroprotective role of a key Alzheimer risk variant, TREM2^R47H, against tau-mediated neurodegeneration in a mouse model of tauopathy. This study highlights the context-dependent response of microglia, and proposes antagonistic roles of TREM2 in Aβ- versus tau-mediated pathology.

Keywords: Alzheimer’s disease; TREM2; microglia; tauopathy.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Alzheimer Disease*
Animals
Disease Models, Animal
Gliosis*
Membrane Glycoproteins
Mice
Microglia
Receptors, Immunologic

Substances

Membrane Glycoproteins
Receptors, Immunologic
Trem2 protein, mouse