Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis

Jhansi L Leslie; Erin Weddle; Lauren K Yum; Ye Lin; Matthew L Jenior; Benjamin Lee; Jennie Z Ma; Beth D Kirkpatrick; Uma Nayak; James A Platts-Mills; Herve F Agaisse; Rashidul Haque; William A Petri

doi:10.1093/cid/ciaa1409

Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis

Clin Infect Dis. 2021 Jun 1;72(11):e868-e871. doi: 10.1093/cid/ciaa1409.

Authors

Affiliations

¹ Department of Medicine, Division of International Health and Infectious Diseases, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
² Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
³ Department of Statistics, University of Virginia, Charlottesville, Virginia, USA.
⁴ Department of Biomedical Engineering, University of Virginia School of Medicine and School of Engineering, Charlottesville, Virginia, USA.
⁵ Vaccine Testing Center and Department of Pediatrics, The University of Vermont College of Medicine, Burlington, Vermont, USA.
⁶ Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
⁷ Department of Medicine and Vaccine Testing Center, The University of Vermont College of Medicine, Burlington, Vermont, USA.
⁸ Center for Public Health Genomics and Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
⁹ International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.

Abstract

In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis.

Keywords: Lewis antigens; blood-group antigens; shigellosis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Dysentery, Bacillary*
Humans
Infant
Lewis Blood Group Antigens

Substances

Lewis Blood Group Antigens

Abstract

Publication types

MeSH terms

Substances

Grants and funding