The appearance of a new coronavirus (Covid-19) and its rapid expansion throughout the world has forced all countries to establish regulations based on social confinement. In the early days of a pandemic, the adherence to regulations is crucial to be able to block its spread. This research aims to analyse the relationship between motivational variables associated with physical distancing and self-interested consumption behaviours in the first 10 days of confinement in Spain. A total of 1,324 people participated throughout the country (mean age 28.92 years). Participants answered an online survey about socio-demographic, motivational variables, which included a) risk information seeking, b) confidence in self- and collective efficacy in coping with the pandemic, and c) the four higher-order personal values ‒conservation (security, conformity, and tradition), self-transcendence (universalism and benevolence), openness (self-direction actions and stimulation), and self-improvement (hedonism and power) ‒ and the aforementioned behaviours in coping with Covid-19. Results showed a positive association between self- and collective efficacy and both coping behaviours analysed: a protective role of conservation values on normative behaviours; and a negative relationship between self-transcendence values and self-interested consumption. Additionally, risk information seeking was positively associated with the development of physical distancing behaviour.