Drug Resistance Spread in 6 Metropolitan Regions, Germany, 2001-20181

Emerg Infect Dis. 2020 Oct;26(10):2439-2443. doi: 10.3201/eid2610.191506.

Abstract

We analyzed 1,397 HIV-1 pol sequences of antiretroviral therapy-naive patients in a total of 7 university hospitals in Bonn, Cologne, Frankfurt, Hamburg, Hannover, and Munich, Germany. Phylogenetic and network analysis elucidated numerous cases of shared drug resistance mutations among genetically linked patients; K103N was the most frequently shared mutation.

Trial registration: ClinicalTrials.gov NCT02149004.

Keywords: ART; Germany; HIV transmission; antimicrobial resistance; antiretroviral therapy; mutations; phylogenetic analysis; public health.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents* / pharmacology
  • Anti-HIV Agents* / therapeutic use
  • Drug Resistance, Viral / genetics
  • Genotype
  • Germany / epidemiology
  • HIV Infections* / drug therapy
  • HIV Infections* / epidemiology
  • HIV-1* / genetics
  • Humans
  • Mutation
  • Phylogeny

Substances

  • Anti-HIV Agents

Associated data

  • ClinicalTrials.gov/NCT02149004