Neutralization of P blood group antibodies by synthetic solid-phase antigens

Transfusion. 1987 May-Jun;27(3):272-5. doi: 10.1046/j.1537-2995.1987.27387235638.x.

Abstract

P blood group system antibodies are encountered frequently in clinical transfusion practice. The authors describe an improved method for removing P antibodies from patient specimens without dilution. Solid-phase synthetic P antigens were used to neutralize serums containing P blood group system antibodies; 26 alloantibodies with specificity other than P were not inhibited. The synthetic P antigens are also used to characterize the heterogeneous immunochemical fine specificity of antibodies to P1 and P + P1 + Pk.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies / immunology*
  • Antibody Specificity
  • Antigens*
  • Blood Group Antigens / immunology*
  • Humans
  • Immunosorbent Techniques
  • Isoantibodies / analysis
  • Isoantibodies / immunology
  • Male
  • Neutralization Tests / methods*
  • P Blood-Group System / immunology*
  • Vaccines, Synthetic* / immunology

Substances

  • Antibodies
  • Antigens
  • Blood Group Antigens
  • Isoantibodies
  • P Blood-Group System
  • Vaccines, Synthetic