Harmonization of antineutrophil cytoplasmic antibodies (ANCA) testing by reporting test result-specific likelihood ratios: position paper

Xavier Bossuyt; Jan Damoiseaux; Niels Rasmussen; Pieter van Paassen; Bernard Hellmich; Bo Baslund; Daniel Blockmans; Pieter Vermeersch; Marcos Lopez-Hoyos; Martine Vercammen; Elisa Barret; Friederike Hammar; Ulrich Leinfelder; Michael Mahler; Nina Olschowka; Dirk Roggenbuck; Wolfgang Schlumberger; Roger Walker; Johan Rönnelid; Jan-Willem Cohen Tervaert; Elena Csernok; Walter Fierz; for (i) the European Federation of Laboratory Medicine (EFLM) Task and Finish Group “Autoimmunity Testing,” (ii) the European Autoimmune Standardization Initiative (EASI) and the (iii) European Consensus Finding Study Group on autoantibodies (ECFSG)

doi:10.1515/cclm-2020-1178

Harmonization of antineutrophil cytoplasmic antibodies (ANCA) testing by reporting test result-specific likelihood ratios: position paper

Clin Chem Lab Med. 2020 Oct 16;59(2):e35-e39. doi: 10.1515/cclm-2020-1178.

Authors

Xavier Bossuyt^{1

2}, Jan Damoiseaux³, Niels Rasmussen⁴, Pieter van Paassen⁵, Bernard Hellmich⁶, Bo Baslund⁷, Daniel Blockmans², Pieter Vermeersch^{8

9}, Marcos Lopez-Hoyos^{10

11}, Martine Vercammen^{12

13}, Elisa Barret¹⁴, Friederike Hammar¹⁵, Ulrich Leinfelder¹⁵, Michael Mahler¹⁶, Nina Olschowka¹⁷, Dirk Roggenbuck¹⁸, Wolfgang Schlumberger¹⁹, Roger Walker¹⁴, Johan Rönnelid²⁰, Jan-Willem Cohen Tervaert²¹, Elena Csernok⁶, Walter Fierz²²; for (i) the European Federation of Laboratory Medicine (EFLM) Task and Finish Group “Autoimmunity Testing,” (ii) the European Autoimmune Standardization Initiative (EASI) and the (iii) European Consensus Finding Study Group on autoantibodies (ECFSG)¹

Affiliations

¹ Clinical and Diagnostic Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven and Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.
² Department of Microbiology, Immunology and Transplantation, KU Leuven and Department of Internal Medicine, University Hospitals Leuven, Leuven, Belgium.
³ Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands.
⁴ Department of Biochemistry and Immunology, Statens Seruminstitut, Copenhagen, Denmark.
⁵ Department of Internal Medicine, Section Nephrology and Immunology, Maastricht University Medical Center, Maastricht, The Netherlands.
⁶ Department of Internal Medicine, Rheumatology and Immunology, University Teaching Hospital Kirchheim, Vasculitis-Center Tübingen-Kirchheim, Kirchheim-Teck, Germany.
⁷ Department of Rheumatology, Rigshospitalet, Copenhagen, Denmark.
⁸ Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
⁹ Department of Laboratory Medicine, University Hospitals Leuven, 3000Leuven, Belgium.
¹⁰ Department of Immunology, University Hospital Marques de Valdecilla-IDIVAL, Santander, Spain.
¹¹ University of Cantabria, Cantabria, Spain.
¹² Department of Laboratory Medicine, AZ Sint-Jan, Brugge-Oostende, Brugge, Belgium.
¹³ Research Group Reproductive Immunology and Implantation (REIM), Vrije Universiteit Brussel (VUB), Ixelles, Belgium.
¹⁴ Clinical Immunology Division, Bio-Rad Laboratories, Hercules, USA.
¹⁵ Orgentec Diagnostika GmbH, Mainz, Germany.
¹⁶ Inova Diagnostics, San Diego, CA, USA.
¹⁷ Thermo Fisher Scientific, Phadia GmbH, Freiburg, Germany.
¹⁸ Medipan GmbH, Dahlewitz/Berlin and Faculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology Cottbus - Senftenberg, The Brandenburg Medical School Theodor Fontane and The University of Potsdam, Senftenberg, Germany.
¹⁹ Euroimmun AG, Lübeck, Germany.
²⁰ Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
²¹ Department of Medicine, University of Alberta, Edmonton, Canada.
²² Schweizerischer Verband der Diagnostikindustrie (SVDI), Bern, Switzerland.

PMID: 33027040
DOI: 10.1515/cclm-2020-1178

No abstract available

Keywords: SARS-CoV-2 antibody; antineutrophil cytoplasmic antibodies (ANCA); harmonization; vasculitis.

Publication types

Letter

MeSH terms

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / blood
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / diagnosis*
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / immunology
Antibodies, Antineutrophil Cytoplasmic / blood*
Calibration
Data Interpretation, Statistical
Diagnosis, Differential
Humans
Immunoassay / methods
Immunoassay / standards*
Likelihood Functions
Myeloblastin / immunology
Peroxidase / immunology
Reference Standards
Sensitivity and Specificity

Substances

Antibodies, Antineutrophil Cytoplasmic
MPO protein, human
Peroxidase
Myeloblastin