Dorsal raphe organization

Abstract

A recent cluster of reports have considerably deepened our understanding of the transcriptional diversity of serotonin neurons of the dorsal raphe nucleus (DR). In this commentary a subset of implications from these studies is highlighted such as: serotonin neurons in the lateral wings have a newly discovered close relationship with those in rostral and dorsal locations and that cre-lines may be just as likely to cut across several transcriptional subtypes as to define a single subtype. To evolve understanding of DR organization, it may be prudent to correlate transcriptional snapshots in time with other known features of DR neurons. Here we bring together new and old information on serotonin neuron diversity with the goal of developing increasingly useful schemes of DR organization.

Keywords: Cell types; Dorsal raphe; Median raphe; Met; Vglut3.