An emerging role of chromatin-interacting RNA-binding proteins in transcription regulation

Essays Biochem. 2020 Dec 7;64(6):907-918. doi: 10.1042/EBC20200004.

Abstract

Transcription factors (TFs) are well-established key factors orchestrating gene transcription, and RNA-binding proteins (RBPs) are mainly thought to participate in post-transcriptional control of gene. In fact, these two steps are functionally coupled, offering a possibility for reciprocal communications between transcription and regulatory RNAs and RBPs. Recently, a series of exploratory studies, utilizing functional genomic strategies, have revealed that RBPs are prevalently involved in transcription control genome-wide through their interactions with chromatin. Here, we present a refined census of RBPs to grope for such an emerging role and discuss the global view of RBP-chromatin interactions and their functional diversities in transcription regulation.

Keywords: 3D genome; RBP; chromatin interaction; gene promoter; transcription regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chromatin / genetics*
  • Chromatin / metabolism*
  • Chromosomes / chemistry
  • Chromosomes / genetics
  • Chromosomes / metabolism
  • DNA / genetics
  • DNA / metabolism
  • Gene Expression
  • Gene Expression Regulation*
  • Genome
  • Humans
  • Promoter Regions, Genetic / genetics
  • Protein Binding / genetics
  • RNA / genetics
  • RNA / metabolism
  • RNA Processing, Post-Transcriptional / genetics
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / metabolism*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcription, Genetic / genetics*

Substances

  • Chromatin
  • RNA-Binding Proteins
  • Transcription Factors
  • RNA
  • DNA