Quantitative PCR-based chimerism in bone marrow or peripheral blood to predict acute myeloid leukemia relapse in high-risk patients: results from the KIM-PB prospective study

Valentina Gambacorta; Riccardo Parolini; Elisabetta Xue; Raffaella Greco; Evelien E Bouwmans; Cristina Toffalori; Fabio Giglio; Andrea Assanelli; Maria Teresa Lupo Stanghellini; Alessandro Ambrosi; Benedetta Mazzi; Wietse Mulder; Consuelo Corti; Jacopo Peccatori; Fabio Ciceri; Luca Vago

doi:10.3324/haematol.2019.238543

Quantitative PCR-based chimerism in bone marrow or peripheral blood to predict acute myeloid leukemia relapse in high-risk patients: results from the KIM-PB prospective study

Haematologica. 2020 Sep 10;106(5):1480-1483. doi: 10.3324/haematol.2019.238543.

Authors

Valentina Gambacorta¹, Riccardo Parolini¹, Elisabetta Xue², Raffaella Greco³, Evelien E Bouwmans⁴, Cristina Toffalori¹, Fabio Giglio³, Andrea Assanelli³, Maria Teresa Lupo Stanghellini³, Alessandro Ambrosi⁵, Benedetta Mazzi⁶, Wietse Mulder⁴, Consuelo Corti³, Jacopo Peccatori³, Fabio Ciceri⁷, Luca Vago⁸

Affiliations

¹ Unit of Immunogenetics, Leukemia Genomics and Immunobiology, IRCCS San Raffaele Scientific Institute, Milano.
² Unit of Immunogenetics, Leukemia Genomics and Immunobiology, IRCCS San Raffaele Scientific Institute, Milano, Italy; Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano.
³ Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano.
⁴ GenDx, Utrecht.
⁵ Vita-Salute San Raffaele University, Milano.
⁶ HLA and Chimerism Laboratory, IRCCS San Raffaele Scientific Institute, Milano.
⁷ Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy; Vita-Salute San Raffaele University, Milano.
⁸ Unit of Immunogenetics, Leukemia Genomics and Immunobiology, IRCCS San Raffaele Scientific Institute, Milano, Italy; Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano. vago.luca@hsr.it.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Bone Marrow
Bone Marrow Transplantation
Chimerism*
Humans
Leukemia, Myeloid, Acute* / diagnosis
Leukemia, Myeloid, Acute* / genetics
Polymerase Chain Reaction
Prospective Studies
Recurrence
Transplantation Chimera

Grants and funding

Funding: the study was supported by the Italian Ministry of Health (RF-2011-02351998 to FC and LV, RF-2011-02348034 to LV and TRANSCAN HLALOSS to LV), by the Associazione Italiana per la Ricerca sul Cancro (Start-Up Grant #14162 to LV) and by the DKMS Mechtild Harf Foundation (DKMS Mechtild Harf Research Grant 2015 to LV).