Sensitivity and specificity of single and combined clouds analyses compared with quantitative motor unit potential analysis

Muscle Nerve. 2021 Feb;63(2):225-230. doi: 10.1002/mus.27106. Epub 2020 Nov 13.

Abstract

Introduction: Turns-amplitude, number of small segments (NSS)-activity, and envelope-activity clouds are three methods of electromyography (EMG) interference pattern analysis. Our objective was to evaluate the sensitivity and specificity of each individual cloud analysis and combined clouds analysis to compare with that of quantitative motor unit potential (QMUP) analysis.

Methods: A total of 379 muscles from 100 patients were analyzed by both QMUP and clouds analyses. Calculation of sensitivity and specificity was based on the clinical diagnosis as the "gold standard."

Results: For discrimination of abnormal vs normal and neuropathic vs non-neuropathic, combined clouds analysis had greater sensitivity than QMUP analysis and any single cloud analysis, but there were no differences in specificity. For discrimination of myopathic vs non-myopathic, combined clouds analysis and single cloud analysis had greater sensitivity than QMUP analysis, but there were no differences in specificity.

Discussion: Combined clouds analysis was superior to QMUP and each single cloud analysis for distinguishing normal, myopathic, and neuropathic muscles.

Keywords: electromyography, envelope-activity cloud, interference pattern analysis, NSS-activity cloud, quantitative motor unit potential, turns-amplitude cloud.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Amyotrophic Lateral Sclerosis / diagnosis
  • Amyotrophic Lateral Sclerosis / physiopathology
  • Dermatomyositis / diagnosis
  • Dermatomyositis / physiopathology
  • Diagnosis, Differential
  • Electrodiagnosis
  • Electromyography / methods*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mononeuropathies / diagnosis
  • Mononeuropathies / physiopathology
  • Motor Neuron Disease / diagnosis*
  • Motor Neuron Disease / physiopathology
  • Muscle, Skeletal / physiopathology*
  • Muscular Atrophy, Spinal / diagnosis
  • Muscular Atrophy, Spinal / physiopathology
  • Muscular Diseases / diagnosis*
  • Muscular Diseases / physiopathology
  • Muscular Dystrophies / diagnosis
  • Muscular Dystrophies / physiopathology
  • Myositis / diagnosis
  • Myositis / physiopathology
  • Peripheral Nervous System Diseases / diagnosis*
  • Peripheral Nervous System Diseases / physiopathology
  • Polyneuropathies / diagnosis
  • Polyneuropathies / physiopathology
  • Radiculopathy / diagnosis
  • Radiculopathy / physiopathology
  • Recruitment, Neurophysiological
  • Sensitivity and Specificity
  • Signal Processing, Computer-Assisted
  • Spinal Muscular Atrophies of Childhood / diagnosis
  • Spinal Muscular Atrophies of Childhood / physiopathology
  • Young Adult

Supplementary concepts

  • Amyotrophy, monomelic