CD34 expression does not correlate with immunophenotypic stem cell or progenitor content in human cord blood products

Blood Adv. 2020 Nov 10;4(21):5357-5361. doi: 10.1182/bloodadvances.2020002891.

Authors

Sruthi Mantri¹, Andreas Reinisch², Beruh T Dejene¹, Deirdre J Lyell³, David L DiGiusto¹, Rajni Agarwal-Hashmi¹, Ravindra Majeti², Kenneth I Weinberg¹, Matthew H Porteus¹

Affiliations

¹ Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics.
² Division of Hematology, Department of Medicine, and.
³ Division of Maternal-Fetal Medicine and Obstetrics, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA.

Abstract

The CD34⁺ compartment of human cord blood contains a range of HSPC immunophenotypes, among which the Lin⁻CD34⁺CD38⁺CD127⁺ CLP is rare.
There is no correlation between the frequencies of CD34⁺ cells and immunophenotypic HSC in umbilical cord blood products.

MeSH terms

Antigens, CD34
Fetal Blood*
Humans
Immunophenotyping
Stem Cells*

Substances

Antigens, CD34

Grants and funding

R01 HL142637/HL/NHLBI NIH HHS/United States