Total-Body PET Imaging in Infectious Diseases

Timothy J Henrich; Terry Jones; Denis Beckford-Vera; Patricia M Price; Henry F VanBrocklin

doi:10.1016/j.cpet.2020.09.011

Total-Body PET Imaging in Infectious Diseases

PET Clin. 2021 Jan;16(1):89-97. doi: 10.1016/j.cpet.2020.09.011. Epub 2020 Nov 5.

Authors

Timothy J Henrich¹, Terry Jones², Denis Beckford-Vera³, Patricia M Price⁴, Henry F VanBrocklin³

Affiliations

¹ Division of Experimental Medicine, University of California San Francisco, 1001 Potrero Avenue, Building 3, Room 525A, San Francisco, CA 94110, USA. Electronic address: Timothy.Henrich@ucsf.edu.
² Department of Radiology, University of California Davis Medical Center, Sacramento, CA, USA.
³ Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
⁴ Department of Surgery and Cancer, Imperial College, London, UK.

Abstract

Total-body PET enables high-sensitivity imaging with dramatically improved signal-to-noise ratio. These enhanced performance characteristics allow for decreased PET scanning times acquiring data "total-body wide" and can be leveraged to decrease the amount of radiotracer required, thereby permitting more frequent imaging or longer imaging periods during radiotracer decay. Novel approaches to PET imaging of infectious diseases are emerging, including those that directly visualize pathogens in vivo and characterize concomitant immune responses and inflammation. Efforts to develop these imaging approaches are hampered by challenges of traditional imaging platforms, which may be overcome by novel total-body PET strategies.

Keywords: COVID-19; Human immunodeficiency syndrome; Infectious diseases; T cells; Total-body PET.

Publication types

Review

MeSH terms

Communicable Diseases / diagnostic imaging*
Humans
Positron-Emission Tomography / methods*
Signal-To-Noise Ratio
Time
Whole Body Imaging / methods*

Abstract

Publication types

MeSH terms

Grants and funding