Microglia Tweak Retinogeniculate Pathways during Visual Circuit Refinement

Neuron. 2020 Nov 11;108(3):397-399. doi: 10.1016/j.neuron.2020.10.018.

Abstract

Cheadle et al. reveal that microglia expressing TWEAK facilitate synapse elimination through a novel, non-phagocytic mechanism in the retinogeniculate pathway during visual circuit development. This mechanism is experience-dependent and occurs through the local binding of TWEAK to postsynaptic Fn14.

Publication types

  • Comment

MeSH terms

  • Microglia*
  • Receptors, Tumor Necrosis Factor
  • TWEAK Receptor / genetics
  • Tumor Necrosis Factors*

Substances

  • Receptors, Tumor Necrosis Factor
  • TWEAK Receptor
  • Tumor Necrosis Factors