Updates in Pediatric Glioma Pathology

Surg Pathol Clin. 2020 Dec;13(4):801-816. doi: 10.1016/j.path.2020.08.006. Epub 2020 Oct 9.

Abstract

Gliomas are a diverse group of primary central nervous system tumors with astrocytic, oligodendroglial, and/or ependymal features and are an important cause of morbidity/mortality in pediatric patients. Glioma classification relies on integrating tumor histology with key molecular alterations. This approach can help establish a diagnosis, guide treatment, and determine prognosis. New categories of pediatric glioma have been recognized in recent years, due to increasing application of molecular profiling in brain tumors. The aim of this review is to alert pediatric pathologists to emerging diagnostic concepts in pediatric glioma neuropathology, emphasizing the incorporation of molecular features into diagnostic practice.

Keywords: Astrocytoma; Glioblastoma; Glioma; Molecular profiling; Pediatric.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor
  • Brain Neoplasms / classification
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / genetics
  • Brain Neoplasms / pathology*
  • Child
  • Glioma / classification
  • Glioma / diagnosis
  • Glioma / genetics
  • Glioma / pathology*
  • Humans
  • Mutation
  • Prognosis

Substances

  • Biomarkers, Tumor