Abstract
We developed a new strategy to overcome the MDR of etoposide using self-assembling nanofibers. Compared with the original etoposide, the inhibitory activity of Nap-GFFpYK-etoposide1/2 against murine Lewis lung cancer or breast cancer cells was increased 10 times, and 20 times on these cells with artificially overexpressed MDR1. Our method to synthesize and separate etoposide isomers provides a new strategy for the modification of this drug.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B / genetics
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ATP Binding Cassette Transporter, Subfamily B / metabolism
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects
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Cell Line, Tumor
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Cell Membrane Permeability
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Drug Carriers / chemistry*
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Drug Compounding
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Drug Liberation
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Drug Resistance, Multiple
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Drug Resistance, Neoplasm
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Etoposide / chemistry*
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Gene Expression Regulation / drug effects
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Humans
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Mice
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Nanofibers / chemistry*
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Optical Imaging
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Peptides / chemical synthesis*
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Peptides / pharmacology
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Solid-Phase Synthesis Techniques
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Spectrometry, Fluorescence
Substances
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ABCB1 protein, human
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ATP Binding Cassette Transporter, Subfamily B
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Antineoplastic Agents
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Drug Carriers
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Peptides
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Etoposide