Surgical Management of Colorectal Cancer Liver Metastases

Chandrasekhar Padmanabhan; Daniel P Nussbaum; Michael D'Angelica

doi:10.1016/j.soc.2020.09.002

Surgical Management of Colorectal Cancer Liver Metastases

Surg Oncol Clin N Am. 2021 Jan;30(1):1-25. doi: 10.1016/j.soc.2020.09.002.

Authors

Chandrasekhar Padmanabhan¹, Daniel P Nussbaum¹, Michael D'Angelica²

Affiliations

¹ Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, C-1272, New York, NY 10065, USA.
² Memorial Sloan Kettering Cancer Center, 1275 York Avenue, C-898, New York, NY 10065, USA. Electronic address: DangeliM@mskcc.org.

PMID: 33220799
DOI: 10.1016/j.soc.2020.09.002

Abstract

Approximately 50% of colorectal cancer patients develop liver metastases. Hepatic metastases represent the most common cause of colorectal cancer-related mortality. Metastasectomy, if possible, represents the most effective treatment strategy; 20% of patients will be cured and more than 50% survive at least 5 years. Nuances to treatment planning hinge on whether patients present with resectable disease upfront, whether the future liver remnant is adequate, and whether the primary tumor, if present, is colon versus rectal in origin. This article discusses considerations impacting our approach to patients with colorectal liver metastases and the role for various multimodal treatment options.

Keywords: Colon cancer; Colorectal cancer; Liver metastases; Rectal cancer.

Publication types

Review

MeSH terms

Colorectal Neoplasms*
Combined Modality Therapy
Humans
Liver Neoplasms* / surgery
Metastasectomy*