Sometimes even apoptosis fails: implications for cancer

Kevin Berthenet; Kathrin Weber; Gabriel Ichim

doi:10.1080/23723556.2020.1797430

Sometimes even apoptosis fails: implications for cancer

Mol Cell Oncol. 2020 Aug 23;7(6):1797430. doi: 10.1080/23723556.2020.1797430.

Authors

Kevin Berthenet^{1

2}, Kathrin Weber¹, Gabriel Ichim^{1

2}

Affiliations

¹ Cancer Research Center of Lyon (CRCL) INSERM 1052, CNRS 5286, Lyon, France.
² Cancer Cell Death Laboratory, Part of LabEx DEVweCAN, Université de Lyon, Lyon, France.

Abstract

Apoptosis is vital for the correct morphogenesis of multi-cellular organisms. However, like most physiological programs, the cell's ability to commit suicide is hijacked by cancer in its own proliferative and invasive interest. We recently showed that inefficient execution of apoptosis (or failed apoptosis) is used by cancer to boost invasiveness.

Keywords: Failed apoptosis; MOMP; cancer; caspases; invasiveness.

Grants and funding

This work was supported by funding from LabEx DEVweCAN (University of Lyon), Agence Nationale de la Recherche (ANR) Young Researchers Project (ANR-18-CE13-0005-01), Rhône-Alpes and Saône-et-Loire Ligue Contre le Cancer grant and the ANR PLAsCAN Institute.