Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology

Camille R Simoneau; Melanie Ott

doi:10.1016/j.stem.2020.11.012

Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology

Cell Stem Cell. 2020 Dec 3;27(6):859-868. doi: 10.1016/j.stem.2020.11.012.

Authors

Camille R Simoneau¹, Melanie Ott²

Affiliations

¹ Gladstone Institute of Virology, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA.
² Gladstone Institute of Virology, San Francisco, CA, USA; Department of Medicine, University of California San Francisco, San Francisco, CA, USA. Electronic address: melanie.ott@gladstone.ucsf.edu.

Abstract

SARS-CoV-2, the virus causing the current COVID-19 pandemic, primarily targets the airway epithelium and in lungs can lead to acute respiratory distress syndrome. Clinical studies in recent months have revealed that COVID-19 is a multi-organ disease causing characteristic complications. Stem cell models of various organ systems-most prominently, lung, gut, heart, and brain-are at the forefront of studies aimed at understanding the role of direct infection in COVID-19 multi-organ dysfunction.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

COVID-19 / complications*
COVID-19 / physiopathology
Humans
Models, Biological*
Stem Cells*

Abstract

Publication types

MeSH terms

Grants and funding