Docetaxel-Induced Interstitial Pneumonitis Detected on 68Ga-PSMA PET/CT

Clin Nucl Med. 2021 May 1;46(5):e268-e269. doi: 10.1097/RLU.0000000000003445.

Abstract

68Ga-PSMA PET/CT is a commonly performed procedure in the staging of intermediate- and high-risk prostate cancer after biochemical recurrence. Uptake of 68Ga-PSMA in benign conditions is also reported in the literature. Docetaxel is the mainstay of treatment in high-volume hormone-sensitive prostate cancer and castration-resistant prostate cancer. The major treatment-emergent adverse drug reactions attributed to docetaxel include myelosuppression, alopecia, and asthenia. Interstitial pneumonitis is seen in less than 2% of docetaxel-treated patients. We present a case of metastatic castration-resistant prostate cancer, wherein docetaxel-induced interstitial pneumonitis was detected on 68Ga-PSMA PET/CT, after docetaxel treatment.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Docetaxel / adverse effects*
  • Docetaxel / therapeutic use
  • Edetic Acid / analogs & derivatives*
  • Gallium Isotopes
  • Gallium Radioisotopes
  • Humans
  • Lung Diseases, Interstitial / chemically induced*
  • Lung Diseases, Interstitial / diagnostic imaging*
  • Male
  • Oligopeptides*
  • Positron Emission Tomography Computed Tomography*
  • Prostatic Neoplasms / drug therapy
  • Prostatic Neoplasms / pathology

Substances

  • Gallium Isotopes
  • Gallium Radioisotopes
  • Oligopeptides
  • gallium 68 PSMA-11
  • Docetaxel
  • Edetic Acid