Severe Acute Respiratory Syndrome Coronavirus 2 Lethality Did not Change Over Time in Two Italian Provinces

Maria Elena Flacco; Cecilia Acuti Martellucci; Francesca Bravi; Giustino Parruti; Alfonso Mascitelli; Lorenzo Mantovani; Stefania Boccia; Lamberto Manzoli

doi:10.1093/ofid/ofaa556

Severe Acute Respiratory Syndrome Coronavirus 2 Lethality Did not Change Over Time in Two Italian Provinces

Open Forum Infect Dis. 2020 Nov 12;7(12):ofaa556. doi: 10.1093/ofid/ofaa556. eCollection 2020 Dec.

Authors

Maria Elena Flacco¹, Cecilia Acuti Martellucci², Francesca Bravi³, Giustino Parruti⁴, Alfonso Mascitelli⁵, Lorenzo Mantovani^{6

7}, Stefania Boccia^{8

9}, Lamberto Manzoli¹

Affiliations

¹ Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
² Department of Biomedical Sciences and Public Health, University of the Marche Region, Ancona, Italy.
³ "Sant'Anna" University Hospital of Ferrara, Ferrara, Italy.
⁴ Local Health Authority of Pescara, Pescara, Italy.
⁵ Regional Healthcare Agency of Abruzzo, Pescara, Italy.
⁶ School of Medicine and Surgery, University Bicocca, Milan, Italy.
⁷ IRCCS Multimedica, Sesto San Giovanni, Italy.
⁸ Department of Health Sciences and Public Health, Catholic University of the Sacred Heart, Rome, Italy.
⁹ Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Abstract

This retrospective cohort study included all the subjects diagnosed with severe acute respiratory syndrome coronavirus 2 infection (n = 2493) in 2 Italian provinces. Two hundred fifty-eight persons died, after a median of 14.0 ± 11.0 days. Adjusting for age, gender, and main comorbidities, the ≥28-day case-fatality rate did not decrease from March to April 2020 (adjusted hazard ratio, 0.93; P = .6).

Keywords: COVID-19; SARS-CoV-2; case-fatality rate; lethality; trend over time.