New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions

Bei Guo; Tongtian Zhuang; Feng Xu; Xiao Lin; Fuxingzi Li; Su-Kang Shan; Feng Wu; Jia-Yu Zhong; Yi Wang; Ming-Hui Zheng; Qiu-Shuang Xu; Ullah Muhammad Hasnain Ehsan; Ling-Qing Yuan

doi:10.3389/fphys.2020.570270

New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions

Front Physiol. 2020 Dec 3:11:570270. doi: 10.3389/fphys.2020.570270. eCollection 2020.

Authors

Affiliations

¹ National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory of Metabolic Bone Diseases, and Department of Endocrinology and Metabolism, The Second Xiangya Hospital, Central South University, Changsha, China.
² Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
³ Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
⁴ Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China.

Abstract

Adipose tissue, as the largest endocrine organ, secretes many biologically active molecules circulating in the bloodstream, collectively termed adipocytokines, which not only regulate the metabolism but also play a role in pathophysiological processes. C1q tumor necrosis factor (TNF)-related protein 3 (CTRP3) is a member of C1q tumor necrosis factor-related proteins (CTRPs), which is a paralog of adiponectin. CTRP3 has a wide range of effects on glucose/lipid metabolism, inflammation, and contributes to cardiovascular protection. In this review, we comprehensively discussed the latest research on CTRP3 in obesity, diabetes, metabolic syndrome, and cardiovascular diseases.

Keywords: CTRP3; adipocytokines; cardiovascular disorders; insulin resistance; metabolic syndrome; obesity; therapeutic targets; type 2 diabetes mellitus.

Publication types

Review