To solve overfitting in machine learning, we propose a novel data augmentation method called MeshCut, which uses a mesh-like mask to segment the whole image to achieve more partial diversified information. In our experiments, this strategy outperformed the existing augmentation strategies and achieved state-of-the-art results in a variety of computer vision tasks. MeshCut is also an easy-to-implement strategy that can efficiently improve the performance of the existing convolutional neural network models by a good margin without careful hand-tuning. The performance of such a strategy can be further improved by incorporating it into other augmentation strategies, which can make MeshCut a promising baseline strategy for future data augmentation algorithms.