A multi-institutional outbreak of New Delhi metallo-β-lactamase-producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene

Infect Control Hosp Epidemiol. 2021 Sep;42(9):1124-1127. doi: 10.1017/ice.2020.1361. Epub 2020 Dec 29.

Abstract

We characterized 57 isolates from a 2-phase clonal outbreak of New Delhi metallo-β-lactamase-producing Eschericha coli, involving 9 Israeli hospitals; all but 1 isolate belonged to sequence-type (ST) 410. Most isolates in the second phase harbored blaKPC-2 in addition to blaNDM-5. Genetic sequencing revealed most dual-carbapenemase-producing isolates to be monophyletically derived from a common ancestor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins
  • Disease Outbreaks*
  • Escherichia coli / genetics
  • Escherichia coli / isolation & purification*
  • Escherichia coli Infections / epidemiology
  • Escherichia coli Infections / microbiology*
  • Humans
  • Israel / epidemiology
  • Klebsiella pneumoniae* / enzymology
  • Klebsiella pneumoniae* / genetics
  • beta-Lactamases

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • beta-Lactamases
  • beta-lactamase NDM-1
  • carbapenemase