Does gouty nephropathy exist, and is it more common than we think?

Federica Piani; Richard J Johnson

doi:10.1016/j.kint.2020.10.015

Does gouty nephropathy exist, and is it more common than we think?

Kidney Int. 2021 Jan;99(1):31-33. doi: 10.1016/j.kint.2020.10.015.

Authors

Federica Piani¹, Richard J Johnson²

Affiliations

¹ Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address: richard.johnson@ucdenver.edu.
² Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

PMID: 33390238
DOI: 10.1016/j.kint.2020.10.015

Abstract

Gout is present in one third of subjects with CKD but is usually an exclusion criterion in clinical trials investigating the role of uric acid in kidney disease. Bardin et al. report that one third of gouty subjects have hyperechoic medullas by ultrasound (consistent with crystalline deposits) that correlates with increased risk for hypertension and kidney dysfunction and which were not observed in >500 controls. If validated, a "gouty nephropathy" from microcrystalline deposits could be an important, unrecognized cause of CKD.

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MeSH terms

Cross-Sectional Studies
Gout* / epidemiology
Humans
Kidney Medulla*
Ultrasonography
Uric Acid

Substances

Uric Acid