mSphere of Influence: the Complexity of Interferon Gamma-Mediated Pathogen Control

Bryan D Bryson

doi:10.1128/mSphere.01295-20

mSphere of Influence: the Complexity of Interferon Gamma-Mediated Pathogen Control

mSphere. 2021 Jan 6;6(1):e01295-20. doi: 10.1128/mSphere.01295-20.

Author

Bryan D Bryson^{1

2}

Affiliations

¹ Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA bryand@mit.edu.
² Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.

Abstract

Bryan D. Bryson works in the field of biological engineering with a specific interest in host-mycobacterium interactions. In this mSphere of Influence article, he reflects on how "IRG1 and inducible nitric oxide synthase act redundantly with other interferon-gamma-induced factors to restrict intracellular replication of Legionella pneumophila" by Price and colleagues (J. V. Price, D. Russo, D. X. Ji, R. A. Chavez, et al., mBio 10:e02629-19, 2019, https://doi.org/10.1128/mBio.02629-19) made an impact on him by reinforcing the complexity of intracellular pathogen control.

Keywords: Legionella pneumophila; interferon gamma; macrophage.

MeSH terms

Host-Pathogen Interactions* / genetics
Host-Pathogen Interactions* / immunology
Humans
Immunity, Innate / genetics*
Interferon-gamma / immunology*
Legionella pneumophila / immunology*
Legionella pneumophila / pathogenicity
Narration
Nitric Oxide Synthase Type II
Phagosomes / immunology
Phagosomes / microbiology
Protein Transport

Substances

Interferon-gamma
NOS2 protein, human
Nitric Oxide Synthase Type II