Relationship between Intraocular Pressure and Coffee Consumption in a Japanese Population without Glaucoma: The Nagahama Study

Eri Nakano; Masahiro Miyake; Yoshikatsu Hosoda; Yuki Mori; Kenji Suda; Takanori Kameda; Hanako Ikeda-Ohashi; Yasuharu Tabara; Kenji Yamashiro; Hiroshi Tamura; Tadamichi Akagi; Fumihiko Matsuda; Akitaka Tsujikawa; Nagahama Study Group

doi:10.1016/j.ogla.2020.09.019

Relationship between Intraocular Pressure and Coffee Consumption in a Japanese Population without Glaucoma: The Nagahama Study

Ophthalmol Glaucoma. 2021 May-Jun;4(3):268-276. doi: 10.1016/j.ogla.2020.09.019. Epub 2020 Nov 5.

Affiliations

¹ Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
² Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: miyakem@kuhp.kyoto-u.ac.jp.
³ Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
⁴ Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
⁵ Department of Ophthalmology, Otsu Red-Cross Hospital, Otsu, Japan.

PMID: 33518504
DOI: 10.1016/j.ogla.2020.09.019

Abstract

Purpose: To evaluate the association between daily coffee consumption and intraocular pressure (IOP) in healthy persons without glaucoma and the association between daily coffee consumption and history of glaucoma.

Design: Cross-sectional study.

Participants: A total of 9850 individuals participated in the first follow-up of the Nagahama Prospective Cohort for Comprehensive Human Bioscience (the Nagahama Study) conducted between 2013 and 2016.

Methods: All participants underwent a standardized ophthalmic examination. Self-reporting questionnaires were completed by all participants. First, the association between habitual coffee consumption and IOP among nonglaucoma individuals was evaluated by a multivariate linear regression analysis, adjusting for possible confounders. Second, the association between habitual coffee consumption and history of glaucoma also was evaluated using a multivariate logistic regression analysis.

Main outcome measures: The association between habitual coffee consumption and IOP among nonglaucoma individuals.

Results: Of 9850 participants, 9418 did not have history of glaucoma. Among these participants, the mean ± standard deviation IOP of both eyes was 14.7 ± 2.9 mmHg. The multivariate regression analysis revealed that habitual coffee consumption was associated significantly with IOP (P < 0.001): the higher the consumption of coffee, the lower the IOP of an individual. The IOP of the group who consumed coffee most frequently (3 times daily or more) was 0.4 mmHg lower (95% confidence interval, 0.2-0.5 mmHg lower) than that of the group that consumed coffee least frequently (less than once daily). However, the logistic regression analysis showed that habitual coffee consumption was not associated significantly with history of glaucoma (P = 0.53).

Conclusions: Frequent coffee consumption was associated with a slightly lower IOP in people without glaucoma but was not associated with a decreased risk of glaucoma developing. Additional experimental studies are needed to examine the effects of coffee on IOP and glaucoma risk.

Keywords: Coffee; Coffee consumption; Glaucoma; Intraocular pressure; Nagahama Study.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Coffee* / adverse effects
Cross-Sectional Studies
Glaucoma* / epidemiology
Humans
Intraocular Pressure
Japan / epidemiology
Prospective Studies

Substances

Coffee