IRGM1, a guardian of mitochondrial DAMP-mediated autoinflammation

Brett A Kaufman; Ana L Mora

doi:10.1038/s41590-021-00877-6

IRGM1, a guardian of mitochondrial DAMP-mediated autoinflammation

Nat Immunol. 2021 Mar;22(3):272-273. doi: 10.1038/s41590-021-00877-6.

Authors

Brett A Kaufman¹, Ana L Mora²

Affiliations

¹ Center for Metabolism and Mitochondrial Medicine, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
² Aging Institute, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. anamora@pitt.edu.

Abstract

IRGM1 is recognized as a master regulator of type I interferon responses against pathogens, while also protecting against autoimmune diseases. It has now been shown that IRGM1 controls autoinflammatory responses by modulating mitophagy flux.

Publication types

Comment

MeSH terms

Autoimmunity*
GTP-Binding Proteins*
Mitochondria / metabolism

Substances

GTP-Binding Proteins

Abstract

Publication types

MeSH terms

Substances

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