RETRACTED: circTulp4 functions in Alzheimer’s disease pathogenesis by regulating its parental gene, Tulp4

Mol Ther. 2021 Jun 2;29(6):2167-2181. doi: 10.1016/j.ymthe.2021.02.008. Epub 2021 Feb 10.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern has been raised by a reader that research reported in the article duplicates figures and reuses data from prior publications without attribution. After investigation of the concerns raised, the editors found the following reuse of data without attribution: Figure 1B in this article is identical to Ma et al., 2020, FASEB J. 34, 10342–10356, https://doi.org/10.1096/fj.201903157R, Figure 2B. Figure 1D in this article is identical to Ma et al., 2019, Mol. Ther. Nucleic Acids 18, 1049–1062, https://doi.org/10.1016/j.omtn.2019.10.030, Figure 2A. Figure 1F in this article is identical to Ma et al., 2019, Mol. Ther. Nucleic Acids 18, 1049–1062, https://doi.org/10.1016/j.omtn.2019.10.030, Figure 2B. Figure 1A in this article reuses data from Ma et al., 2020, FASEB J. 34, 10342–10356, https://doi.org/10.1096/fj.201903157R, Figure 2E. Figure S1 in this article is identical to Ma et al., 2019, Mol. Ther. Nucleic Acids 18, 1049–1062, https://doi.org/10.1016/j.omtn.2019.10.030, Figure 3 One of the conditions of submission of a paper for publication is that authors declare explicitly that the paper has not been previously published and is not under consideration for publication elsewhere. As such this article represents a misuse of the scientific publishing system. The corresponding authors have agreed to the retraction.

Keywords: Alzheimer’s disease; Tulp4; U1 snRNP; circRNA; circTulp4; neuronal differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Alzheimer Disease / etiology*
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Animals
  • Biomarkers
  • Cell Differentiation / genetics
  • Disease Models, Animal
  • Disease Susceptibility
  • Gene Expression Profiling
  • Gene Expression Regulation*
  • Gene Knockdown Techniques
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Mice
  • Mice, Transgenic
  • Models, Biological
  • Neuronal Outgrowth
  • Neurons / cytology
  • Neurons / metabolism
  • Nucleotide Motifs
  • RNA Polymerase II / metabolism
  • RNA Transport
  • RNA, Circular*

Substances

  • Biomarkers
  • Intracellular Signaling Peptides and Proteins
  • RNA, Circular
  • Tulp4 protein, mouse
  • RNA Polymerase II