Co-occurrence of mcr-1 and mcr-8 genes in multi-drug-resistant Klebsiella pneumoniae from a 2015 clinical isolate

S Hala; C P Antony; A A Momin; M Alshehri; F Ben-Rached; G Al-Ahmadi; S Zakri; M Baadhaim; A Alsaedi; O A Al Thaqafi; S T Arold; A Al-Amri; A Pain

doi:10.1016/j.ijantimicag.2021.106303

Co-occurrence of mcr-1 and mcr-8 genes in multi-drug-resistant Klebsiella pneumoniae from a 2015 clinical isolate

Int J Antimicrob Agents. 2021 Mar;57(3):106303. doi: 10.1016/j.ijantimicag.2021.106303. Epub 2021 Feb 13.

Authors

S Hala¹, C P Antony², A A Momin³, M Alshehri⁴, F Ben-Rached⁵, G Al-Ahmadi⁶, S Zakri⁴, M Baadhaim⁴, A Alsaedi⁴, O A Al Thaqafi⁷, S T Arold³, A Al-Amri⁴, A Pain⁸

Affiliations

¹ Pathogen Genomics Laboratory, Division of Biological and Environmental Sciences and Engineering, Thuwal, Makkah, Saudi Arabia; King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Makkah, Saudi Arabia; King Abdullah International Medical Research Centre, Jeddah, Makkah, Saudi Arabia; Ministry of National Guard Health Affairs, Jeddah Makkah, Saudi Arabia.
² Pathogen Genomics Laboratory, Division of Biological and Environmental Sciences and Engineering, Thuwal, Makkah, Saudi Arabia; Red Sea Research Centre, Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Saudi Arabia.
³ Computational Bioscience Research Centre, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, Makkah, Saudi Arabia.
⁴ King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Makkah, Saudi Arabia; King Abdullah International Medical Research Centre, Jeddah, Makkah, Saudi Arabia; Ministry of National Guard Health Affairs, Jeddah Makkah, Saudi Arabia.
⁵ Pathogen Genomics Laboratory, Division of Biological and Environmental Sciences and Engineering, Thuwal, Makkah, Saudi Arabia.
⁶ Ministry of National Guard Health Affairs, Jeddah Makkah, Saudi Arabia.
⁷ King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Makkah, Saudi Arabia.
⁸ Pathogen Genomics Laboratory, Division of Biological and Environmental Sciences and Engineering, Thuwal, Makkah, Saudi Arabia; Global Institution for Collaborative Research and Education, Hokkaido University, Kita-ku, Sapporo, Japan. Electronic address: arnab.pain@kaust.edu.sa.

PMID: 33592301
DOI: 10.1016/j.ijantimicag.2021.106303

No abstract available

Publication types

Letter

MeSH terms

Colistin / therapeutic use
Drug Resistance, Multiple, Bacterial / genetics*
Genes, Bacterial / genetics*
Klebsiella Infections / drug therapy
Klebsiella Infections / microbiology*
Klebsiella pneumoniae / drug effects
Klebsiella pneumoniae / genetics*
Microbial Sensitivity Tests
Multilocus Sequence Typing
Plasmids / genetics

Substances

Colistin