Synthesis of magnetic covalent organic framework molecularly imprinted polymers at room temperature: A novel imprinted strategy for thermo-sensitive substance

Qianyu Zhao; Chao Ma; Jingyi Liu; Zilong Chen; Haitian Zhao; Bin Li; Xin Yang

doi:10.1016/j.talanta.2020.121958

Synthesis of magnetic covalent organic framework molecularly imprinted polymers at room temperature: A novel imprinted strategy for thermo-sensitive substance

Talanta. 2021 Apr 1:225:121958. doi: 10.1016/j.talanta.2020.121958. Epub 2020 Dec 13.

Authors

Qianyu Zhao¹, Chao Ma¹, Jingyi Liu¹, Zilong Chen², Haitian Zhao¹, Bin Li², Xin Yang³

Affiliations

¹ School of Chemistry and Chemical Engineering, Harbin Institute of Technology, No.92, West Dazhi Street, Nangang District, Harbin, Heilongjiang, 150001, China.
² School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Jiangxi, Nanchang, 330004, China.
³ School of Chemistry and Chemical Engineering, Harbin Institute of Technology, No.92, West Dazhi Street, Nangang District, Harbin, Heilongjiang, 150001, China. Electronic address: yangxin@hit.edu.cn.

PMID: 33592713
DOI: 10.1016/j.talanta.2020.121958

Abstract

Molecularly imprinted polymers (MIPs) with specific selective recognition have shown excellent performance in the rapid and efficient separation and enrichment of targets in complex systems. Unfortunately, it is not suitable for thermosensitive substances with biological functions. To this end, an imine-linked MIPs with covalent organic frameworks and magnetic nanoparticles was developed by using a room temperature synthesis strategy for the purification of Cyaninin-3-O-glucoside (C3G) from black chokeberry. The prepared material recognized C3G through π-π interaction, assisted by hydrogen bond, and will not be disturbed by water environment. The adsorption capacity and equilibrium binding constant were 86.92 mg g^-1 and 1.46 L mg^-1, respectively. Based on this special structure, it can also act as a "protective umbrella" and improve the stability of C3G. Furthermore, it exhibited high selectivity compared with dummy template imprinting technique. After purification, the purity of C3G was obviously improved (from 11.96% to 84.72%). This work provided a new strategy for the selective separation of anthocyanin and a method to develop MIPs for thermosensitive substances.

Keywords: Covalent organic frameworks; Cyanidin-3-O-Glucoside; Molecularly imprinted polymers; Room temperature synthesis; Stabilization technology.