CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice

Circ Res. 2021 Apr 30;128(9):1258-1275. doi: 10.1161/CIRCRESAHA.120.318688. Epub 2021 Feb 24.

¹ Queens Medical Research Institute, BHF Centre for Cardiovascular Sciences (F.V., J.R., M.K.L., A.D.M., M.B., E.M., J.P.S., D.E.N., P.W.F.H., L.D., J.C.S., A.H.B.), University of Edinburgh, Scotland.
² Institute for Regeneration and Repair, Centre for Regenerative Medicine (A.D.P., D.O.), University of Edinburgh, Scotland.
³ Pathology, Maastricht Medical Center, the Netherlands (K.V.K., J.d., J.C.S., A.H.B.).
⁴ Pathology CARIM, Cardiovascular Research Institute Maastricht, GROW-School for Oncology and Developmental Biology, Maastricht University, the Netherlands (M. Gijbels).
⁵ Insitute of Genetics and Molecular Medicine (T.C.W.), University of Edinburgh, Scotland.
⁶ Centre for Stem Cell Systems, Department of Anatomy and Neuroscience, The University of Melbourne, Australia (M.B.C.).
⁷ Medicine, Vanderbilt University Medical Center, Nashville, Tennessee (A.C.D).
⁸ miRagen Therapeutics, lnc, Boulder, Colorado (R.M.).
⁹ Medical Biochemistry, Experimental Vascular Biology, Amsterdam UMC, University of Amsterdam, the Netherlands (M. Gijbels).
¹⁰ King's College London, England (M. Giacca).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: atherosclerosis; cell proliferation; cholesterol; inflammation; phenotype.