Objective: To explore the research progress of hair follicle and related stem cells in scar-free skin healing in recent years.
Methods: The literature related to hair follicle and related stem cells, wound healing, and scar formation in recent years was extensively reviewed and summarized from the aspects of cell function and molecular mechanism.
Results: Scar tissue after wound healing treated with hair follicle transplantation and related stem cell therapy is more mild or even without scar formation. The cell types and molecular mechanisms of the above phenomena are complex, and the bone morphogenetic protein signal transduction pathway and Wnt signal transduction pathway are strongly correlated.
Conclusion: The research of hair follicle and related stem cells in scar-free skin healing is at the initial stage at present. Strengthening the mechanism research may provide new ideas for the treatment of wound and scar.
目的: 综述毛囊及相关干细胞在创面无瘢痕愈合中的研究进展。.
方法: 广泛查阅近年国内外毛囊及相关干细胞与创面愈合及瘢痕形成的相关文献，从细胞功能及分子机制等方面进行总结讨论。.
结果: 创面经毛囊及相关干细胞移植治疗愈合后形成的瘢痕更轻微，甚至无瘢痕形成。上述现象涉及的细胞种类及分子机制复杂，目前主要明确了与 BMP 信号通路及 Wnt 信号通路强相关。.
结论: 毛囊及相关干细胞在创面无瘢痕愈合方面的研究尚处于起步阶段，需要加强机制研究，以期为创面和瘢痕的治疗提供新思路。.
Keywords: Hair follicle; dermal papilla cells; dermal sheath cells; hair follicle stem cells; scarring; wound healing.