Vascular Endothelial Damage in the Pathogenesis of Organ Injury in Severe COVID-19

Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):1760-1773. doi: 10.1161/ATVBAHA.120.315595. Epub 2021 Feb 25.

¹ Univ. Lille Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000 Lille, France (A. Dupont, A.R., S. Staessens, M.M., M.R., D.C., E.J., F.L., B.S., F.V., N.R., S. Susen).
² CHU Lille, Intensive Care Department, Pôle de Réanimation, France (J.G., M.C.).
³ University of Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, France (P.V., G.L.).
⁴ CHU Lille, Institut d'Hématologie-Transfusion, France (A.B.).
⁵ University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, UMR1019-CIIL, France (K.F.).
⁶ University of Lille, Inserm, CHU Lille, INSERM U 1167, Institut Pasteur, France (M.L.).
⁷ University of Lille, CHU Lille, ULR 2694 - METRICS: Évaluation des technologies de santé et des pratiques médicales, France (A. Duhamel, J.L.).
⁸ CHU Lille, Surgical Critical Care, Department of Anesthesiology and Critical Care, France (D.G.).
⁹ Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, Belgium (S.F.D.M.).
¹⁰ University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, France (E.K.).
¹¹ Inserm, UMR_1176, Université Paris-Saclay, France (P.L.).
¹² University of Lille, Inserm U1285, CHU Lille, CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, France (J.P.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: coronavirus; cytokines; death; endothelium; thrombosis.