Editor's Choice - Systematic Review and Meta-Analysis of the Effect of Weekend Admission on Outcomes for Ruptured Abdominal Aortic Aneurysms: A Call for an Equitable Seven Day Vascular Service

Eur J Vasc Endovasc Surg. 2021 May;61(5):767-778. doi: 10.1016/j.ejvs.2020.12.022. Epub 2021 Feb 22.

Abstract

Objective: "The weekend effect" of higher patient mortality when presenting at a weekend compared with a weekday has been established for several conditions. The aim of this study was to investigate whether a weekend effect exists for the emergency condition of ruptured abdominal aortic aneurysm.

Data sources: A review of the literature was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines (PROSPERO registration number CRD42020157484). MEDLINE, EMBASE and CINAHL were searched using the Healthcare Databases Advanced Search interface developed by NICE.

Review methods: The prognostic factor of interest was weekend admission. The primary outcome of interest was all cause peri-operative mortality, with a secondary outcome of hospital length of stay. A random effects meta-analysis was performed, and the results were reported as summary odds ratio (OR) and 95% confidence interval (CI).

Results: Twelve observational cohort studies published between 2001 and 2019 comprising 14 patient cohorts with a total of 95 856 patients were eligible for quantitative synthesis. Patients presenting on a weekend had a significantly higher risk of unadjusted in hospital mortality (OR 1.20, 95% CI 1.10 - 1.31, p < .001). Both the unadjusted 30 day mortality risk (OR 1.16, 95% CI 0.98 - 1.39, p = .090) and unadjusted 90 day mortality risk (OR 1.12, 95% CI 0.90 - 1.40, p = .30) were higher for those presenting at a weekend, but neither reached statistical significance. There was a significantly greater risk of combined unadjusted in hospital, 30 and 90 day mortality for those presenting at a weekend (OR 1.17, 95% CI 1.09 - 1.27, p < .001). Hospital length of stay was not statistically different between groups.

Conclusion: There is an association between weekend admission and higher mortality in patients presenting with ruptured abdominal aortic aneurysm.

Keywords: Meta-analysis; Ruptured abdominal aortic aneurysm; Weekend effect.

Publication types

  • Comparative Study
  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Aortic Aneurysm, Abdominal / complications
  • Aortic Aneurysm, Abdominal / mortality
  • Aortic Aneurysm, Abdominal / surgery*
  • Aortic Rupture / etiology
  • Aortic Rupture / mortality
  • Aortic Rupture / surgery*
  • Conservative Treatment / adverse effects
  • Conservative Treatment / statistics & numerical data
  • Emergency Service, Hospital / statistics & numerical data
  • Emergency Treatment / adverse effects*
  • Emergency Treatment / statistics & numerical data
  • Hospital Mortality
  • Humans
  • Observational Studies as Topic
  • Odds Ratio
  • Perioperative Period / statistics & numerical data
  • Postoperative Complications / epidemiology*
  • Postoperative Complications / etiology
  • Prognosis
  • Risk Assessment / statistics & numerical data
  • Risk Factors
  • Time Factors
  • Treatment Outcome
  • Vascular Surgical Procedures / adverse effects
  • Vascular Surgical Procedures / statistics & numerical data