Diabetes and Metabolic Drivers of Trained Immunity: New Therapeutic Targets Beyond Glucose

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1284-1290. doi: 10.1161/ATVBAHA.120.314211. Epub 2021 Mar 4.

Abstract

[Figure: see text].

Keywords: hematopoiesis; homeostasis; immunity; macrophages; metabolism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Atherosclerosis / genetics
  • Atherosclerosis / immunology
  • Atherosclerosis / metabolism
  • Biomarkers / blood
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism*
  • Cellular Reprogramming*
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / genetics
  • Diabetes Mellitus / immunology
  • Diabetes Mellitus / metabolism*
  • Endothelial Cells / immunology
  • Endothelial Cells / metabolism
  • Energy Metabolism* / drug effects
  • Energy Metabolism* / genetics
  • Epigenesis, Genetic
  • Hematopoiesis
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Myeloid Progenitor Cells / immunology
  • Myeloid Progenitor Cells / metabolism
  • Signal Transduction

Substances

  • Biomarkers
  • Blood Glucose
  • Hypoglycemic Agents