A Study on the Correlation Between MDR1 Polymorphism and Clopidogrel Resistance in Hui Patients Treated with Percutaneous Coronary Intervention

Fang Chen; Jing Zhang; Cheng-Xue Bian; Jian Zhang; Xiang-Bin Xin; Yang-Yang Pan; Xuan Zhang

doi:10.2147/IJGM.S293947

A Study on the Correlation Between MDR1 Polymorphism and Clopidogrel Resistance in Hui Patients Treated with Percutaneous Coronary Intervention

Int J Gen Med. 2021 Feb 25:14:665-671. doi: 10.2147/IJGM.S293947. eCollection 2021.

Authors

Fang Chen¹, Jing Zhang², Cheng-Xue Bian², Jian Zhang³, Xiang-Bin Xin², Yang-Yang Pan², Xuan Zhang²

Affiliations

¹ Department of Cardiology, Yinchuan First People's Hospital, Yinchuan, People's Republic of China.
² Department of Cardiology, Ningxia Medical University, Yinchuan, People's Republic of China.
³ Department of Clinical Laboratory, Yinchuan First People's Hospital, Yinchuan, People's Republic of China.

Abstract

Objective: This study assesses the correlation between MDR1 gene polymorphism and clopidogrel resistance (CR) in Hui patients with coronary heart disease (CHD) who were treated with percutaneous coronary intervention (PCI).

Methods: The study includes 204 Ningxia Hui patients with CHD who were treated with PCI. These patients were divided into two groups: those who with CR and others were non-clopidogrel resistant (NCR), according to the results of the patients' platelet aggregation rate, which was tested by adenosine diphosphate-induced turbidimetry on the second postoperative day. C3435T and C1236T genotypes and alleles were tested by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).

Results: The CR rate was 24.0%, and there were 3 genotypes of C3435T and C1236T. For C3435T, the distribution frequency of the 3435TT genotype and T allele was significantly higher in the CR group than in the NCR group. For C1236T, no significant difference was found between the two groups.

Conclusion: Hui patients who had CHD were treated with PCI. CR was most likely to occur in those who had the T allele of MDR1 in gene C3435T.

Keywords: MDR1 gene; clopidogrel resistance; coronary heart disease; gene polymorphism; platelet aggregation rate.

Grants and funding

Source of supports: Ningxia Science and Technology Support Project (Grant No. 2012ZYS212). The funding body plays no role in designing the studies and collections, analysis, and interpretation of data and writing the manuscript as well.