When Eating Becomes a Pain in the Gut

Taylor Adair; Gabrielle T Belz

doi:10.1016/j.it.2021.02.008

When Eating Becomes a Pain in the Gut

Trends Immunol. 2021 Apr;42(4):273-275. doi: 10.1016/j.it.2021.02.008. Epub 2021 Mar 2.

Authors

Taylor Adair¹, Gabrielle T Belz²

Affiliations

¹ The University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane 4102, Australia.
² The University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane 4102, Australia; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne 3010, Australia. Electronic address: g.belz@uq.edu.au.

PMID: 33674226
DOI: 10.1016/j.it.2021.02.008

Abstract

Irritable bowel syndrome often appears following gastrointestinal infection and is marked by diarrhea, dysbiosis, fever, and intestinal pain following eating. A recent study by Aguilera-Lizarraga et al. now demonstrates that a breakdown in intestinal immunotolerance sparks an inflammatory response to typically tolerated food antigens and causes visceral pain.

Keywords: enteric nervous system; gastrointestinal immune response; gut immunology; mast cells; neuroimmunology.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Diarrhea
Dysbiosis*
Humans
Irritable Bowel Syndrome*
Pain