A totally OSM gift to astrocytes relieves inflammation

Angela A Wang; Jennifer L Gommerman

doi:10.1016/j.immuni.2021.02.011

A totally OSM gift to astrocytes relieves inflammation

Immunity. 2021 Mar 9;54(3):401-403. doi: 10.1016/j.immuni.2021.02.011.

Authors

Angela A Wang¹, Jennifer L Gommerman²

Affiliations

¹ Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: angelaar.wang@mail.utoronto.ca.
² Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: jen.gommerman@utoronto.ca.

PMID: 33691129
DOI: 10.1016/j.immuni.2021.02.011

Abstract

Dectin-1 is known for promoting anti-fungal responses through the signaling molecule Card9. In this issue of Immunity, Deerhake et al. now report that during autoimmune neuroinflammation, Dectin-1 can promote a neuroprotective feed-forward pathway through Card9-independent upregulation of Oncostatin M.

Publication types

Comment

MeSH terms

Astrocytes* / metabolism
Humans
Inflammation
Oncostatin M / metabolism
Signal Transduction*
Up-Regulation

Substances

OSM protein, human
Oncostatin M