Transmission Routes of Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers of a French University Hospital in Paris, France

Adrien Contejean; Jérémie Leporrier; Etienne Canouï; Jacques Fourgeaud; Alice-Andrée Mariaggi; Fanny Alby-Laurent; Emmanuel Lafont; Lauren Beaudeau; Claire Rouzaud; Fabienne Lecieux; Agnès Greffet; Anne-Sophie L'Honneur; Jean-Marc Tréluyer; Fanny Lanternier; Anne Casetta; Pierre Frange; Marianne Leruez-Ville; Flore Rozenberg; Olivier Lortholary; Solen Kernéis

doi:10.1093/ofid/ofab054

Transmission Routes of Severe Acute Respiratory Syndrome Coronavirus 2 Among Healthcare Workers of a French University Hospital in Paris, France

Open Forum Infect Dis. 2021 Feb 2;8(3):ofab054. doi: 10.1093/ofid/ofab054. eCollection 2021 Mar.

Authors

Adrien Contejean^{1

2}, Jérémie Leporrier³, Etienne Canouï², Jacques Fourgeaud^{4

5}, Alice-Andrée Mariaggi⁶, Fanny Alby-Laurent^{1

3}, Emmanuel Lafont^{1

3}, Lauren Beaudeau², Claire Rouzaud³, Fabienne Lecieux⁷, Agnès Greffet⁸, Anne-Sophie L'Honneur⁶, Jean-Marc Tréluyer^{9

10

11}, Fanny Lanternier^{1

3}, Anne Casetta¹², Pierre Frange^{5

13}, Marianne Leruez-Ville^{4

5}, Flore Rozenberg^{6

14}, Olivier Lortholary^{1

3

15}, Solen Kernéis^{2

16

17}

Affiliations

¹ Université de Paris, Faculté de Médecine, Paris, France.
² Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.
³ Service de maladies Infectieuses et Tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.
⁴ Laboratoire de Virologie, AP-HP, Hôpital Necker-Enfants malades, Paris, France.
⁵ EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris, France.
⁶ Département de Virologie, AP-HP, Hôpital Cochin, Paris, France.
⁷ Service de Santé au Travail, AP-HP, Hôpital Cochin, Paris, France.
⁸ Service de Santé au Travail, AP-HP, Hôpital Necker-Enfants malades, Paris, France.
⁹ Département de Soins Intensifs Pédiatriques, AP-HP, Hôpital Necker-Enfants malades, Paris, France.
¹⁰ Pharmacology and Drug Evaluation in Children and Pregnant Women EA7323, Université de Paris, Faculté de Médecine, Paris, France.
¹¹ Département de Pharmacologie Clinique AP-HP, Hôpital Cochin, Paris, France.
¹² Equipe opérationnelle d'hygiène Hospitalière, AP-HP, Hôpital Cochin, Paris, France.
¹³ Laboratoire de Microbiologie Clinique, AP-HP, Hôpital Necker-Enfants malades, Paris, France.
¹⁴ Université de Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
¹⁵ Institut Pasteur, Molecular Mycology Unit, National Reference Centre for Invasive Mycoses and Antifungals, CNRS UMR 2000, Paris, France.
¹⁶ Université de Paris, INSERM, IAME, Paris, France.
¹⁷ Institut Pasteur, Epidemiology and Modelling of Antibiotic Evasion (EMAE), Paris, France.

Abstract

In this case-control study on 564 healthcare workers of a university hospital in Paris (France), contacts without protection with coronavirus disease 2019 (COVID-19) patients or with colleagues were associated with infection with severe acute respiratory syndrome coronavirus 2, whereas working in a COVID-dedicated unit and having children kept in childcare facilities were not.

Keywords: COVID-19; SARS-CoV-2; case-control study; determinants; healthcare workers.