Predicting Readmission After Anterior, Posterior, and Posterior Interbody Lumbar Spinal Fusion: A Neural Network Machine Learning Approach

World Neurosurg. 2021 Jul:151:e19-e27. doi: 10.1016/j.wneu.2021.02.114. Epub 2021 Mar 18.

Abstract

Background: Readmission after spine surgery is costly and a relatively common occurrence. Previous research identified several risk factors for readmission; however, the conclusions remain equivocal. Machine learning algorithms offer a unique perspective in analysis of risk factors for readmission and can help predict the likelihood of this occurrence. This study evaluated a neural network (NN), a supervised machine learning technique, to determine whether it could predict readmission after 3 lumbar fusion procedures.

Methods: The American College of Surgeons National Surgical Quality Improvement Program database was queried between 2009 and 2018. Patients who had undergone anterior, lateral, and/or posterior lumbar fusion were included in the study. The Python scikit Learn package was used to run the NN algorithm. A multivariate regression was performed to determine risk factors for readmission.

Results: There were 63,533 patients analyzed (12,915 anterior lumbar interbody fusion, 27,212 posterior lumbar interbody fusion, and 23,406 posterior spinal fusion cases). The NN algorithm was able to successfully predict 30-day readmission for 94.6% of anterior lumbar interbody fusion, 94.0% of posterior lumbar interbody fusion, and 92.6% of posterior spinal fusion cases with area under the curve values of 0.64-0.65. Multivariate regression indicated that age >65 years and American Society of Anesthesiologists class >II were linked to increased risk for readmission for all 3 procedures.

Conclusions: The accurate metrics presented indicate the capability for NN algorithms to predict readmission after lumbar arthrodesis. Moreover, the results of this study serve as a catalyst for further research into the utility of machine learning in spine surgery.

Keywords: Artificial neural network; Lumbar arthrodesis outcomes; Machine learning.

MeSH terms

  • Adult
  • Aged
  • Algorithms
  • Arthrodesis / adverse effects
  • Arthrodesis / methods
  • Databases, Factual
  • Female
  • Hospital Mortality
  • Humans
  • Lumbar Vertebrae / surgery
  • Machine Learning*
  • Male
  • Middle Aged
  • Neural Networks, Computer*
  • Patient Readmission / statistics & numerical data
  • Predictive Value of Tests
  • Retrospective Studies
  • Risk Factors
  • Spinal Fusion / adverse effects*
  • Spinal Fusion / methods
  • Spinal Fusion / mortality
  • Treatment Outcome