Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor

Youwen Zhuang; Brian Krumm; Huibing Zhang; X Edward Zhou; Yue Wang; Xi-Ping Huang; Yongfeng Liu; Xi Cheng; Yi Jiang; Hualiang Jiang; Cheng Zhang; Wei Yi; Bryan L Roth; Yan Zhang; H Eric Xu

doi:10.1038/s41422-021-00482-0

Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor

Cell Res. 2021 May;31(5):593-596. doi: 10.1038/s41422-021-00482-0. Epub 2021 Mar 9.

Authors

Youwen Zhuang^#^{1

2}, Brian Krumm^#³, Huibing Zhang^#^{4

5}, X Edward Zhou⁶, Yue Wang^{1

2}, Xi-Ping Huang³, Yongfeng Liu³, Xi Cheng⁷, Yi Jiang^{1

2}, Hualiang Jiang⁷, Cheng Zhang⁸, Wei Yi⁹, Bryan L Roth¹⁰, Yan Zhang^{11

12

13}, H Eric Xu^{14

15}

Affiliations

¹ The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7365, USA.
⁴ Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.
⁵ MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.
⁶ Center for Cancer and Cell Biology, Program for Structural Biology, Van Andel Research Institute, Grand, Rapids, MI, USA.
⁷ State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
⁸ Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
⁹ Key Laboratory of Molecular Target & Clinical Pharmacology, and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China.
¹⁰ Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7365, USA. bryan_roth@med.unc.edu.
¹¹ Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China. zhang_yan@zju.edu.cn.
¹² MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China. zhang_yan@zju.edu.cn.
¹³ Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang, 311121, China. zhang_yan@zju.edu.cn.
¹⁴ The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. Eric.Xu@simm.ac.cn.
¹⁵ University of Chinese Academy of Sciences, Beijing, 100049, China. Eric.Xu@simm.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Allosteric Regulation
Dopamine*
Humans
Receptors, Dopamine D1*
Synaptic Transmission

Substances

DRD1 protein, human
Receptors, Dopamine D1
Dopamine

Publication types

MeSH terms

Substances

Grants and funding