A Case of Severe COVID-19 in a Patient with Acute Graft-versus-Host Disease after Haploidentical Transplantation

Dan Han; Yuqian Sun; Rong Xie; Xiaojian Zhu; Zhaodong Zhong

doi:10.1155/2021/8878803

A Case of Severe COVID-19 in a Patient with Acute Graft-versus-Host Disease after Haploidentical Transplantation

Case Rep Hematol. 2021 Mar 17:2021:8878803. doi: 10.1155/2021/8878803. eCollection 2021.

Authors

Dan Han¹, Yuqian Sun², Rong Xie¹, Xiaojian Zhu³, Zhaodong Zhong¹

Affiliations

¹ Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
² Peking University Institute of Hematology, Peking University People's Hospital, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing 100044, China.
³ Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Abstract

We report a case of coronavirus disease 2019 (COVID-19) after haploidentical transplantation with acute graft-versus-host disease (aGVHD). COVID-19 and aGVHD were improved under treatment with arbidol, remdesivir, methylprednisolone, and ruxolitinib. However, eventually, the patient died of septic shock and multiple organ failure. It was concluded that the disease condition of this COVID-19 patient after transplantation was serious, complex, and variable, with poor prognosis.

Publication types

Case Reports