Isolation of a new phenazine antibiotic, DOB-41, from Pseudomonas species

J Antibiot (Tokyo). 1988 May;41(5):589-94. doi: 10.7164/antibiotics.41.589.

Abstract

A new phenazine antibiotic, DOB-41, was isolated from the culture broth of a Pseudomonas strain. The antibiotic obtained as yellow crystals showed UV maxima at 255 nm and 370 nm. A molecular formula, C19H18N2O6, was indicated by elemental analysis and mass spectrometry. The structure was elucidated by X-ray diffraction analysis. The antibiotic exhibited inhibitory activity against Gram-positive bacteria, and antitumor effect against leukemia P388 in mice.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / therapeutic use
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / therapeutic use
  • Drug Evaluation, Preclinical
  • Gram-Positive Bacteria / drug effects
  • Leukemia P388 / drug therapy
  • Mice
  • Phenazines / isolation & purification
  • Phenazines / pharmacology
  • Phenazines / therapeutic use
  • Pseudomonas / analysis
  • Pseudomonas / classification
  • Spectrum Analysis
  • X-Ray Diffraction

Substances

  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Phenazines
  • DOB-41 antibiotic