A "KU" new sensor for cytosolic DNA in T cells

Jianjun Wu; Nan Yan

doi:10.1016/j.immuni.2021.03.017

A "KU" new sensor for cytosolic DNA in T cells

Immunity. 2021 Apr 13;54(4):603-605. doi: 10.1016/j.immuni.2021.03.017.

Authors

Jianjun Wu¹, Nan Yan²

Affiliations

¹ Department of Immunology, University of Texas Southwestern Medical School, Dallas, TX, USA.
² Department of Immunology, University of Texas Southwestern Medical School, Dallas, TX, USA; Department of Microbiology, University of Texas Southwestern Medical School, Dallas, TX, USA. Electronic address: nan.yan@utsouthwestern.edu.

PMID: 33852824
DOI: 10.1016/j.immuni.2021.03.017

Abstract

Adaptive immune cells are usually not equipped with pattern recognition receptors. In this issue of Immunity, Wang et al. revealed an "innate-like" cytosolic DNA-sensing mechanism by the KU complex in aged CD4⁺ T cells, which exacerbates aging-related autoimmunity.

Publication types

Comment

MeSH terms

Cytosol
DNA
Immunity, Innate*
Receptors, Pattern Recognition
Signal Transduction*

Substances

Receptors, Pattern Recognition
DNA