The articles in this special issue of AIDS focus on the application of the so-called Big Data science (BDS) as applied to a variety of HIV-applied research questions in the sphere of health services and epidemiology. Recent advances in technology means that a critical mass of HIV-related health data with actionable intelligence is available for optimizing health outcomes, improving and informing surveillance. Data science will play a key but complementary role in supporting current efforts in prevention, diagnosis, treatment, and response needed to end the HIV epidemic. This collection provides a glimpse of the promise inherent in leveraging the digital age and improved methods in Big Data science to reimagine HIV treatment and prevention in a digital age.
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